Rr381^em4Kap
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr381^em4Kap
• Name: regulatory region 381; endonuclease-mediated mutation 4, Dietmar J Kappes
• MGI ID: MGI:7439138
• Synonyms: Sil^ProxRx, ThPOK^SilProxRx
• Gene: Rr381 Location: Chr3:89303454-89303824 bp Genetic Position: Chr3, Syntenic
• Alliance: Rr381^em4Kap page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Other
• Mutation details: The Zbtb7b silencer was targeted with an ssODN template, coding for a version of the silencer sequence where a 40 bp sequence of a highly conserved noncoding element (HCNE; located at the 3' end) containing two conserved Runx binding motifs is moved to the 5' end, using TALEN technology (ZNF target sequences (capitalized) ACCGCTACCCTAACCcataaCTGGAAGGGGTTTAG). (J:333471)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr381 Mutation: 0 strains or lines available

References

• Original: J:333471 Mookerjee-Basu J, et al., Functional Conservation of a Developmental Switch in Mammals since the Jurassic Age. Mol Biol Evol. 2019 Jan 1;36(1):39-53
• All: 1 reference(s)