Pdgfc^{tm2.1(cre/ERT2)Hdin}
Targeted Allele Detail

Summary

• Symbol: Pdgfc^{tm2.1(cre/ERT2)Hdin}
• Name: platelet-derived growth factor, C polypeptide; targeted mutation 2.1, Hao Ding
• MGI ID: MGI:7439353
• Synonyms: Pdgf-c^CreERT2
• Gene: Pdgfc Location: Chr3:80943723-81121347 bp, + strand Genetic Position: Chr3, 35.73 cM
• Alliance: Pdgfc^{tm2.1(cre/ERT2)Hdin} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257668
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Pdgfc^{tm2.1(cre/ERT2)Hdin} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pdgfc (MGI:1859631)

• Mutation details: A FRT flanked SA-IRESbgeo cassette, and T2A-CreERT2 are inserted into exon 6 before the stop codon of the Pdgfc gene. The FRT flanked SA-IRESbgeo cassette was removed by Flpe-mediated recombination. (J:257668)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdgfc (mouse) Summary of all recombinase alleles driven by Pdgfc. Comparative matrix view of recombinase activities Alliance mouse Pdgfc gene page

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfc Mutation: 35 strains or lines available

References

• Original: J:257668 Wu X, et al., A Pdgf-c(CreERT2) knock-in mouse model for tracing PDGF-C cell lineages during development. Genesis. 2018 Feb;56(2)
• All: 1 reference(s)