Rr170^tm1.1Iku
Targeted Allele Detail

Summary

• Symbol: Rr170^tm1.1Iku
• Name: regulatory region 170; targeted mutation 1.1, Koichi Ikuta
• MGI ID: MGI:7439372
• Synonyms: CNS1^-
• Gene: Rr170 Location: Chr15:9533370-9533783 bp Genetic Position: Chr15, Syntenic
• Alliance: Rr170^tm1.1Iku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333539
• Parent Cell Line: KY1.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A 839 bp sequence, containing an Il7r enhancer located upstream of the gene, was replaced with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. (J:333539)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr170 Mutation: 0 strains or lines available

References

• Original: J:333539 Abe A, et al., An Enhancer of the IL-7 Receptor alpha-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells. J Immunol. 2015 Oct 1;195(7):3129-38
• All: 1 reference(s)