Tg(ITGAM-cre/ERT2)F9Jckr
Transgene Detail

Summary

• Symbol: Tg(ITGAM-cre/ERT2)F9Jckr
• Name: transgene insertion, Mathias Jucker
• MGI ID: MGI:7439393
• Synonyms: CD11b-CreERT2
• Transgene: Tg(ITGAM-cre/ERT2)F9Jckr Location: unknown
• Alliance: Tg(ITGAM-cre/ERT2)F9Jckr page

Transgene origin

• Strain of Origin: C57BL/6J C3H/HeJ

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(ITGAM-cre/ERT2)F9Jckr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ITGAM (3684)

  Itgam

  (MGI:96607)

• Mutation details: The transgene consists of the 1,723-bp human CD11b (ITGAM) promoter, a 2,578-bp fragment encoding a rabbit -globin intron and the CreERT2 sequence, a 603-bp transcript-stabilizing WPRE sequence and a 170-bp spanning SV-40 poly(A) sequence. Three founder lines were generated. information and line numbers were not available. The founder line with the most robust and microglia-specific recombination was chosen for further breeding (F9 line). (J:258024)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	ITGAM (human) Summary of all recombinase alleles driven by ITGAM. Comparative matrix view of recombinase activities Alliance human ITGAM gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:258024 Fuger P, et al., Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. Nat Neurosci. 2017 Oct;20(10):1371-1376
• All: 1 reference(s)