Pnpla7^tm1.2Murm
Targeted Allele Detail

Summary

• Symbol: Pnpla7^tm1.2Murm
• Name: patatin-like phospholipase domain containing 7; targeted mutation 1.2, Makoto Murakami
• MGI ID: MGI:7439460
• Gene: Pnpla7 Location: Chr2:24866045-24944069 bp, + strand Genetic Position: Chr2, 16.88 cM
• Alliance: Pnpla7^tm1.2Murm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333442
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct floxed exon 26, which encodes the conserved lipase motif GXSXG. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed the exon. (J:333442)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnpla7 Mutation: 68 strains or lines available

References

• Original: J:333442 Hirabayashi T, et al., Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups. Cell Rep. 2023 Jan 30;42(2):111940
• All: 1 reference(s)