Rr386^em1Pdi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr386^em1Pdi
• Name: regulatory region 386; endonuclease-mediated mutation 1, Priya D Issuree
• MGI ID: MGI:7439579
• Synonyms: Cd4^E4adelta
• Gene: Rr386 Location: Chr6:124878778-124879162 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr386^em1Pdi page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: Effector helper T cell stimulus-responsive Cd4 enhancer E4a was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in a deletion including the enhancer (chr6:124878778-124879162 (GRCm39)). (J:333574)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr386 Mutation: 0 strains or lines available

References

• Original: J:333574 Teghanemt A, et al., CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element. Nat Commun. 2022 Mar 18;13(1):1477
• All: 1 reference(s)