Cep70^em1Qiao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cep70^em1Qiao
• Name: centrosomal protein 70; endonuclease-mediated mutation 1, Jie Qiao
• MGI ID: MGI:7439755
• Gene: Cep70 Location: Chr9:99125420-99182457 bp, + strand Genetic Position: Chr9, 51.45 cM, cytoband F1
• Alliance: Cep70^em1Qiao page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR-targeting of exon 5 inserted 2 bp at two locations (+1/+1) resulting in a frameshift and premature termination. (J:333258)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cep70 Mutation: 84 strains or lines available

References

• Original: J:333258 Liu Q, et al., Loss of CEP70 function affects acrosome biogenesis and flagella formation during spermiogenesis. Cell Death Dis. 2021 May 12;12(5):478
• All: 1 reference(s)