Fer1l5^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Fer1l5^tm1Osb
• Name: fer-1 like family member 5; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7439947
• Gene: Fer1l5 Location: Chr1:36411372-36461191 bp, + strand Genetic Position: Chr1, 15.26 cM
• Alliance: Fer1l5^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333204
• Parent Cell Line: EGR-G101 (ES Cell)
• Strain of Origin: C57BL/6NSlc-Tg(CAG-EGFP,Acr-EGFP)2Osb

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced exons 2 and 3 with a loxP site and an FRT-flanked neomycin resistance cassette in reverse orientation. (J:333204)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fer1l5 Mutation: 51 strains or lines available

References

• Original: J:333204 Morohoshi A, et al., Testis-enriched ferlin, FER1L5, is required for Ca(2+)-activated acrosome reaction and male fertility. Sci Adv. 2023 Jan 25;9(4):eade7607
• All: 1 reference(s)