Ccdc34^em1Fzg
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ccdc34^em1Fzg
• Name: coiled-coil domain containing 34; endonuclease-mediated mutation 1, Feng Zhang
• MGI ID: MGI:7442138
• Gene: Ccdc34 Location: Chr2:109848162-110003705 bp, + strand Genetic Position: Chr2, 56.66 cM
• Alliance: Ccdc34^em1Fzg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• CRISPR-targeting of exon 3 inserted a T (c.562insT) resulting in a frame shift mutation. (J:333018)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc34 Mutation: 25 strains or lines available

References

• Original: J:333018 Cong J, et al., Homozygous mutations in CCDC34 cause male infertility with oligoasthenoteratozoospermia in humans and mice. J Med Genet. 2022 Jul;59(7):710-718
• All: 1 reference(s)