Il25^{tm2.1(icre)Lky}
Targeted Allele Detail

Summary

• Symbol: Il25^{tm2.1(icre)Lky}
• Name: interleukin 25; targeted mutation 2.1, Richard M Locksley
• MGI ID: MGI:7442196
• Synonyms: 25^Cre
• Gene: Il25 Location: Chr14:55170152-55173294 bp, + strand Genetic Position: Chr14, 28.0 cM
• Alliance: Il25^{tm2.1(icre)Lky} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:333765
• Parent Cell Line: PRX-B6T (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Il25^{tm2.1(icre)Lky} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Il25 (MGI:2155888)

• Mutation details: A humanized (eukaryotic codon-optimized) Cre and an FRT flanked neo cassette were inserted in the 3'UTR via homologous recombination. Flp mediated recombination removed the neo cassette. (J:333765)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Il25 (mouse) Summary of all recombinase alleles driven by Il25. Comparative matrix view of recombinase activities Alliance mouse Il25 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il25 Mutation: 16 strains or lines available

References

• Original: J:333765 O'Leary CE, et al., Bile acid-sensitive tuft cells regulate biliary neutrophil influx. Sci Immunol. 2022 Mar 4;7(69):eabj1080
• All: 2 reference(s)