Htr2c^em1(icre)Ylu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Htr2c^em1(icre)Ylu
• Name: 5-hydroxytryptamine (serotonin) receptor 2C; endonuclease-mediated mutation 1, Youming Lu
• MGI ID: MGI:7442224
• Synonyms: Htr2c-Cre
• Gene: Htr2c Location: ChrX:145745509-145980273 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband D-F4
• Alliance: Htr2c^em1(icre)Ylu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Htr2c^em1(icre)Ylu expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Htr2c (MGI:96281)

• Using CRISPR/Cas9 system, P2A-iCRE was inserted between the Htr2c Exon 6 and 3-UTR regions. (J:267056)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Htr2c (mouse) Summary of all recombinase alleles driven by Htr2c. Comparative matrix view of recombinase activities Alliance mouse Htr2c gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr2c Mutation: 13 strains or lines available

References

• Original: J:267056 Li X, et al., Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus. Nat Neurosci. 2018 Sep;21(9):1239-1250
• All: 1 reference(s)