Tg(Gata3-cre)2476Jeng
Transgene Detail

Summary

• Symbol: Tg(Gata3-cre)2476Jeng
• Name: transgene insertion 2476, James Douglas Engel
• MGI ID: MGI:7442301
• Synonyms: Tg^OVE-Cre
• Transgene: Tg(Gata3-cre)2476Jeng Location: unknown
• Alliance: Tg(Gata3-cre)2476Jeng page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gata3-cre)2476Jeng expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gata3 (MGI:95663)

• Mutation details: A 1.3-kb DNA fragment bearing the (300-bp) Gata3 promoter plus 1 kb of the first intron was linked to the 1.5kb genomic sequence of the otic vesicle enhancer (OVE) corresponding to +571 in the Gata3 locus in BAC clone 260A19 drives cre expression to the inner ear specifically. Two lines 2471 and 2476 were established. (J:267996)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gata3 (mouse) Summary of all recombinase alleles driven by Gata3. Comparative matrix view of recombinase activities Alliance mouse Gata3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:267996 Moriguchi T, et al., A Gata3 3' Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression. Mol Cell Biol. 2018 Nov 1;38(21)
• All: 1 reference(s)