Rtel1^{tm4.1(cre/ERT2)Hdin}
Targeted Allele Detail

Summary

• Symbol: Rtel1^{tm4.1(cre/ERT2)Hdin}
• Name: regulator of telomere elongation helicase 1; targeted mutation 4.1, Hao Ding
• MGI ID: MGI:7442434
• Synonyms: Rtel1-CreERT2, Rtel1^CreERT2
• Gene: Rtel1 Location: Chr2:180961532-180998409 bp, + strand Genetic Position: Chr2, 103.63 cM
• Alliance: Rtel1^{tm4.1(cre/ERT2)Hdin} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267997
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Rtel1^{tm4.1(cre/ERT2)Hdin} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Rtel1 (MGI:2139369)

• Mutation details: A FRT flanked SA-IRESbgeo cassette, and T2A-CreERT2 replaced the exon 7 of the Rtel1 gene. The FRT flanked SA-IRESbgeo cassette was removed by Flpe-mediated recombination. (J:267997)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rtel1 (mouse) Summary of all recombinase alleles driven by Rtel1. Comparative matrix view of recombinase activities Alliance mouse Rtel1 gene page

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtel1 Mutation: 75 strains or lines available

References

• Original: J:267997 Seshadri N, et al., Generation of an Rtel1-CreERT2 knock-in mouse model for lineage tracing RTEL1+ stem cells during development. Transgenic Res. 2018 Dec;27(6):571-578
• All: 1 reference(s)