Qpct^tm1.1Gne
Targeted Allele Detail

Summary

• Symbol: Qpct^tm1.1Gne
• Name: glutaminyl-peptide cyclotransferase (glutaminyl cyclase); targeted mutation 1.1, Genentech
• MGI ID: MGI:7442902
• Gene: Qpct Location: Chr17:79359335-79397807 bp, + strand Genetic Position: Chr17, 49.83 cM, cytoband E3
• Alliance: Qpct^tm1.1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:324112
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeted mutation deleted exon 1 and 20bp of intron 1. Flp-mediated recombination removed the FRT-flanked selection cassette. (J:324112)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Qpct Mutation: 8 strains or lines available

References

• Original: J:324112 Barreira da Silva R, et al., Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity. Nat Immunol. 2022 Apr;23(4):568-580
• All: 1 reference(s)