Cxcr5^{em1(cre/ERT2)Yhar}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cxcr5^{em1(cre/ERT2)Yhar}
• Name: C-X-C motif chemokine receptor 5; endonuclease-mediated mutation 1, Yohsuke Harada
• MGI ID: MGI:7443960
• Synonyms: Cxcr5^CreERT2
• Gene: Cxcr5 Location: Chr9:44423084-44437741 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Cxcr5^{em1(cre/ERT2)Yhar} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Cxcr5^{em1(cre/ERT2)Yhar} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cxcr5 (MGI:103567)

• Using the CRISPR/Cas9 system, the P2A sequence and CreERT2 was inserted into the Cxcr5 3'UTR. (J:270146)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cxcr5 (mouse) Summary of all recombinase alleles driven by Cxcr5. Comparative matrix view of recombinase activities Alliance mouse Cxcr5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcr5 Mutation: 28 strains or lines available

References

• Original: J:270146 Takebe T, et al., A novel mouse model for tracking the fate of CXCR5-expressing T cells. Biochem Biophys Res Commun. 2018 Jan 8;495(2):1642-1647
• All: 1 reference(s)