Uri1^{tm2.1(cre/ERT2)Ndj}
Targeted Allele Detail

Summary

• Symbol: Uri1^{tm2.1(cre/ERT2)Ndj}
• Name: URI1, prefoldin-like chaperone; targeted mutation 2.1, Nabil Djouder
• MGI ID: MGI:7444769
• Synonyms: URI^CreERT2, URI-creERT2-IRES-EGFP
• Gene: Uri1 Location: Chr7:37659417-37722976 bp, - strand Genetic Position: Chr7, 25.29 cM
• Alliance: Uri1^{tm2.1(cre/ERT2)Ndj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277739
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Uri1^{tm2.1(cre/ERT2)Ndj} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Uri1 (MGI:1342294)

• Mutation details: A creERT2-IRES-EGFP cassette was inserted immediately after the promoter in exon 1 of the Uri1 gene. The founder mouse was obtained by crossing the chimera to the strain carrying FLPe-recombinase to remove the kanamycin/neomycin cassette. (J:277739)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Uri1 (mouse) Summary of all recombinase alleles driven by Uri1. Comparative matrix view of recombinase activities Alliance mouse Uri1 gene page

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uri1 Mutation: 72 strains or lines available

References

• Original: J:277739 Chaves-Perez A, et al., URI is required to maintain intestinal architecture during ionizing radiation. Science. 2019 May 31;364(6443)
• All: 1 reference(s)