Lemd2^em2Eno
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lemd2^em2Eno
• Name: LEM domain containing 2; endonuclease-mediated mutation 2, Eric N Olson
• MGI ID: MGI:7444807
• Synonyms: Lemd2^fl
• Gene: Lemd2 Location: Chr17:27408574-27423443 bp, - strand Genetic Position: Chr17, 13.82 cM
• Alliance: Lemd2^em2Eno page

Mutation origin

• Strain of Origin: (C57BL/6 x C3H)F2

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Exon 1 was flanked by loxP sites using CRISPR/Cas9 technology. (J:331716)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lemd2 Mutation: 20 strains or lines available

References

• Original: J:331716 Caravia XM, et al., Loss of function of the nuclear envelope protein LEMD2 causes DNA damage-dependent cardiomyopathy. J Clin Invest. 2022 Nov 15;132(22)
• All: 1 reference(s)