Cdh5^{em1(nigri)Bzsh}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdh5^{em1(nigri)Bzsh}
• Name: cadherin 5; endonuclease-mediated mutation 1, Bin Zhou
• MGI ID: MGI:7444934
• Synonyms: Cdh5-Nigri
• Gene: Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cdh5^{em1(nigri)Bzsh} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout, Recombinase)
• Mutation: Insertion
• Cdh5^{em1(nigri)Bzsh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cdh5 (MGI:105057)

• Mutation details: Using CRISPR/Cas9 methods, a cDNA encoding the Nigri (recombinase identified and isolated from bacteria sp Vibrio nigripulchritudo) cassette was inserted into the second exon of the Cdh5 gene. (J:266564)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh5 (mouse) Summary of all recombinase alleles driven by Cdh5. Comparative matrix view of recombinase activities Alliance mouse Cdh5 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh5 Mutation: 59 strains or lines available

References

• Original: J:266564 Liu K, et al., A dual genetic tracing system identifies diverse and dynamic origins of cardiac valve mesenchyme. Development. 2018 Sep 17;145(18):dev167775
• All: 1 reference(s)