Rnf148^em2Zuk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnf148^em2Zuk
• Name: ring finger protein 148; endonuclease-mediated mutation 2, Martin M Matzuk
• MGI ID: MGI:7446290
• Gene: Rnf148 Location: Chr6:23653897-23655135 bp, - strand Genetic Position: Chr6, 11.01 cM, cytoband A3
• Alliance: Rnf148^em2Zuk page

Mutation origin

• Strain of Origin: STOCK Rnf133^em1Zuk/Zuk

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology was used to target Rnf148 for deletion in zygotes containing the Rnf133^em1Zuk allele (carrying a 1070 bp deletion) resulting in a double knock-out allele of both Rnf133 and Rnf148. (J:330415)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf148 Mutation: 26 strains or lines available

References

• Original: J:330415 Nozawa K, et al., The testis-specific E3 ubiquitin ligase RNF133 is required for fecundity in mice. BMC Biol. 2022 Jul 13;20(1):161
• All: 1 reference(s)