Tg(Alb-cre/ERT2)#Nor
Transgene Detail

Summary

• Symbol: Tg(Alb-cre/ERT2)#Nor
• Name: transgene insertion, Alfred Nordheim
• MGI ID: MGI:7446725
• Synonyms: Alf-CreER^T2, Alfp-CreER^T2
• Transgene: Tg(Alb-cre/ERT2)#Nor Location: unknown
• Alliance: Tg(Alb-cre/ERT2)#Nor page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Alb-cre/ERT2)#Nor expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Alb (MGI:87991)

• Mutation details: A cre/ERT2 fusion protein was inserted into a BAC clone (RP23-279P6) containing 200kb sequences including the transcriptional regulatory elements of the Alb (albumin) and Afp (a-fetoprotein) genes in their original chromosomal arrangement. Recombination inserted the CreERT2 cassette within Alb exon1, thereby disrupting Alb coding sequences on the BAC but preserving the promoter and relevant 5 regulatory elements. The expression is restricted to the liver only with tamoxifen-inducible activation. (J:317522)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Alb (mouse) Summary of all recombinase alleles driven by Alb. Comparative matrix view of recombinase activities Alliance mouse Alb gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:317522 Ohrnberger S, et al., Dysregulated serum response factor triggers formation of hepatocellular carcinoma. Hepatology. 2015 Mar;61(3):979-89
• All: 1 reference(s)