Mrc1^{em1(cre/ERT2)Mp}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mrc1^{em1(cre/ERT2)Mp}
• Name: mannose receptor, C type 1; endonuclease-mediated mutation 1, Marco Prinz
• MGI ID: MGI:7446934
• Synonyms: Mrc1^CreERT2
• Gene: Mrc1 Location: Chr2:14234225-14336834 bp, + strand Genetic Position: Chr2, 10.46 cM
• Alliance: Mrc1^{em1(cre/ERT2)Mp} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Mrc1^{em1(cre/ERT2)Mp} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mrc1 (MGI:97142)

• The CRISPRCas9 system was used to knock-in the T2A-CreERT2 cassette into the Mrc1 locus. (J:330324)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mrc1 (mouse) Summary of all recombinase alleles driven by Mrc1. Comparative matrix view of recombinase activities Alliance mouse Mrc1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrc1 Mutation: 86 strains or lines available

References

• Original: J:330324 Masuda T, et al., Specification of CNS macrophage subsets occurs postnatally in defined niches. Nature. 2022 Apr;604(7907):740-748
• All: 3 reference(s)