Aif1^{tm1.1(cre)Mrc}
Targeted Allele Detail

Summary

• Symbol: Aif1^{tm1.1(cre)Mrc}
• Name: allograft inflammatory factor 1; targeted mutation 1.1, Mario R Capecchi
• MGI ID: MGI:7446945
• Synonyms: Aif1(Iba1)-IRES-Cre
• Gene: Aif1 Location: Chr17:35389967-35394977 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Aif1^{tm1.1(cre)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312088
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Aif1^{tm1.1(cre)Mrc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aif1 (MGI:1343098)

• Mutation details: An IRES-Cre-FRT-neo-FRT cassette was inserted into the 3 untranslated region of the Aif1 gene. The neo-selection cassette was removed. (J:312088)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aif1 (mouse) Summary of all recombinase alleles driven by Aif1. Comparative matrix view of recombinase activities Alliance mouse Aif1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aif1 Mutation: 37 strains or lines available

References

• Original: J:312088 Pozner A, et al., Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC::G5-tdT reporter mouse. Front Mol Neurosci. 2015;8:12
• All: 2 reference(s)