Rr397^em1Zyliu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr397^em1Zyliu
• Name: regulatory region 397; endonuclease-mediated mutation 1, Zhiyong Liu
• MGI ID: MGI:7447003
• Synonyms: Eh3^-
• Gene: Rr397 Location: Chr6:64799996-64800902 bp Genetic Position: Chr6, Syntenic
• Alliance: Rr397^em1Zyliu page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: Atoh1 enhancer Eh3 was targeted with sgRNAs (targeting TCGGGGAACTCCTTAACATA and TAAGGGCATAGCCAAAAGTG) using CRISPR/Cas9 technology, resulting in a 907 bp deletion (chr6:64799996-64800902 (GRCm39)) including the enhancer. (J:333396)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr397 Mutation: 0 strains or lines available

References

• Original: J:333396 Luo Z, et al., Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2119850119
• All: 1 reference(s)