Polr2j^em1(IMPC)Bay
Endonuclease-mediated Allele Detail

Summary

• Symbol: Polr2j^em1(IMPC)Bay
• Name: polymerase (RNA) II (DNA directed) polypeptide J; endonuclease-mediated mutation 1, Baylor College of Medicine
• MGI ID: MGI:7447412
• Synonyms: Polr2j^-
• Gene: Polr2j Location: Chr5:136145545-136151801 bp, + strand Genetic Position: Chr5, 75.8 cM, cytoband G1
• Alliance: Polr2j^em1(IMPC)Bay page
• IMPC: Polr2j gene page

Polr2j^em1(IMPC)Bay/Polr2j^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulae or blastocysts. Mutants fail to hatch from the zona pellucida and die after 3 days in culture.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Polr2j Mutation: 16 strains or lines available

References

• Original: J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023
• All: 3 reference(s)