Tg(Prl-cre)#Salr
Transgene Detail

Summary

• Symbol: Tg(Prl-cre)#Salr
• Name: transgene insertion, Stephen A Liebhaber
• MGI ID: MGI:7448387
• Synonyms: Prl-Cre
• Transgene: Tg(Prl-cre)#Salr Location: unknown
• Alliance: Tg(Prl-cre)#Salr page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Prl-cre)#Salr expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prl (MGI:97762)

• Mutation details: A Cre sequence was inserted into the beginning of exon 2 of the Prl ORF in a BAC clone (RP23-441I3 BAC) containing the mouse Prl locus with more than 50 kb of upstream and downstream sequences. The PRL start codon was maintained in the Cre ORF such that the protein product was the first of approximately 10 amino acids of PRL, followed by the full Cre recombinase protein. Founder information and line numbers were not available. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:295321)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prl (mouse) Summary of all recombinase alleles driven by Prl. Comparative matrix view of recombinase activities Alliance mouse Prl gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:295321 Peel MT, et al., The Transcription Factor NR4A2 Plays an Essential Role in Driving Prolactin Expression in Female Pituitary Lactotropes. Endocrinology. 2020 May 1;161(5)
• All: 1 reference(s)