Cfap61^em1Yqt
Chemically induced Allele Detail

Summary

• Symbol: Cfap61^em1Yqt
• Name: cilia and flagella associated protein 61; endonuclease-mediated mutation 1, Yue-Qiu Tan
• MGI ID: MGI:7448443
• Gene: Cfap61 Location: Chr2:145776704-146056959 bp, + strand Genetic Position: Chr2, 71.28 cM
• Alliance: Cfap61^em1Yqt page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas technology deleted exon 3. RT-qPCR confirmed absence of transcript in homozygotes (J:333342)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfap61 Mutation: 63 strains or lines available

References

• Original: J:333342 Hu T, et al., Biallelic CFAP61 variants cause male infertility in humans and mice with severe oligoasthenoteratozoospermia. J Med Genet. 2023 Feb;60(2):144-153
• All: 1 reference(s)