Tg(Ccr2-cre/ERT2)12Kuan
Transgene Detail

Summary

• Symbol: Tg(Ccr2-cre/ERT2)12Kuan
• Name: transgene insertion, Chia-Yi Kuan
• MGI ID: MGI:7448543
• Synonyms: CCR2-CreER(T2)
• Transgene: Tg(Ccr2-cre/ERT2)12Kuan Location: unknown
• Alliance: Tg(Ccr2-cre/ERT2)12Kuan page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Ccr2-cre/ERT2)12Kuan expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ccr2 (MGI:106185)

• Mutation details: The CreERT2 cassette was inserted into the 96-kb mouse BAC (CH25-320O8) containing the mouse Ccr2 gene. Three lines (#21, #49, and #50) from >10 founders were established. Line #21 was used for further studies. (J:314192)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ccr2 (mouse) Summary of all recombinase alleles driven by Ccr2. Comparative matrix view of recombinase activities Alliance mouse Ccr2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:314192 Chen HR, et al., Fate mapping via CCR2-CreER mice reveals monocyte-to-microglia transition in development and neonatal stroke. Sci Adv. 2020 Aug;6(35):eabb2119
• All: 3 reference(s)