Rr401^em1Yushi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr401^em1Yushi
• Name: regulatory region 401; endonuclease-mediated mutation 1, Yuichi Shima
• MGI ID: MGI:7448545
• Synonyms: PE^-
• Gene: Rr401 Location: Chr2:38585614-38586104 bp Genetic Position: Chr2, Syntenic
• Alliance: Rr401^em1Yushi page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Intragenic deletion
• Mutation details: The pituitary gonadotrope-specific Nr5a1 enhancer in intron 6 was targeted with tracrRNAs and crRNAs using CRISPR/Cas9 technology, resulting in its deletion. (J:334319)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr401 Mutation: 0 strains or lines available

References

• Original: J:334319 Shima Y, et al., Intronic Enhancer Is Essential for Nr5a1 Expression in the Pituitary Gonadotrope and for Postnatal Development of Male Reproductive Organs in a Mouse Model. Int J Mol Sci. 2022 Dec 22;24(1)
• All: 1 reference(s)