Arpc5^em1.1Mway
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arpc5^em1.1Mway
• Name: actin related protein 2/3 complex, subunit 5; endonuclease-mediated mutation 1.1, Michael Way
• MGI ID: MGI:7450686
• Gene: Arpc5 Location: Chr1:152642293-152651331 bp, + strand Genetic Position: Chr1, 65.02 cM, cytoband A3
• Alliance: Arpc5^em1.1Mway page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• CRISPR-targeting floxed exon 2. Recombination removed exon 2. (J:334465)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arpc5 Mutation: 8 strains or lines available

References

• Original: J:334465 Sindram E, et al., ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality. Dis Model Mech. 2023 Jul 1;16(7)
• All: 1 reference(s)