Fos^{tm1.1(cre/folA)Mmay}
Targeted Allele Detail

Summary

• Symbol: Fos^{tm1.1(cre/folA)Mmay}
• Name: FBJ osteosarcoma oncogene; targeted mutation 1.1,Mark Mayford
• MGI ID: MGI:7450797
• Synonyms: cfos-ddCre, c-Fos::DD-Cre, Tg(Fos-DD-Cre)
• Gene: Fos Location: Chr12:85520664-85524047 bp, + strand Genetic Position: Chr12, 39.7 cM
• Alliance: Fos^{tm1.1(cre/folA)Mmay} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:334497
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Fos^{tm1.1(cre/folA)Mmay} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fos (MGI:95574)

• Mutation details: A cDNA sequence encoding a mutant destabilizing form (DD) of bacterial dihydrofolate reductase (ecDHFR; folA) attached to cre recombinase cDNA was inserted into the Fos gene locus at the translation start site. Funder mice were crossed to a germline-active flpe expressing transgenic line to remove the PGK-neo cassette. (J:334497)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fos (mouse) Summary of all recombinase alleles driven by Fos. Comparative matrix view of recombinase activities Alliance mouse Fos gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fos Mutation: 43 strains or lines available

References

• Original: J:334497 Dillingham BC, et al., Fear Learning induces long-lasting changes in gene expression and pathway specific presynaptic growth. bioRxiv. 2019
• All: 2 reference(s)