Map3k7tm1.1Arte
Targeted Allele Detail
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Symbol: |
Map3k7tm1.1Arte |
Name: |
mitogen-activated protein kinase kinase kinase 7; targeted mutation 1.1, TaconicArtemis |
MGI ID: |
MGI:7450973 |
Synonyms: |
Map3k7flox |
Gene: |
Map3k7 Location: Chr4:31964097-32023467 bp, + strand Genetic Position: Chr4, 13.91 cM
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Alliance: |
Map3k7tm1.1Arte page
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Germline Transmission: |
Earliest citation of germline transmission:
J:332172
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Parent Cell Line: |
ART B6 3.6 (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: The following sequence was inserted into intron 5: a loxP site, an FRT site flanked neomycin resistance gene cassette, the 3' end of Map3k7 intron 5, Map3k7 exons 6-17 cDNA, human GH poly(A) signal sequences, and an F3 site flanked puromycin resistance gene cassette. Exon 6 was replaced with a version carrying a mutation changing aspartic acid codon 175 (GAT) to alanine (GCT) (p.D175A). The neo and puro cassettes were removed through subsequent Flp-mediated recombination. This allele will express the wild-type peptide from the inserted mini-gene unless conditional Cre-mediated deletion removes the mini-gene, in which case the peptide with the D175A mutation will be expressed. The mutation renders the peptide kinase-dead.
(J:332172)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Map3k7 Mutation: |
52 strains or lines available
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Original: |
J:332172 Rodrigues M, et al., TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells. Biochem J. 2022 Sep 16;479(17):1891-1907 |
All: |
1 reference(s) |
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