Neurog2^{tm2(Ncre)Cschu}
Targeted Allele Detail

Summary

• Symbol: Neurog2^{tm2(Ncre)Cschu}
• Name: neurogenin 2; targeted mutation 2, Carol Schuurmans
• MGI ID: MGI:7451386
• Synonyms: Neurog2^N-CreKI
• Gene: Neurog2 Location: Chr3:127426784-127429280 bp, + strand Genetic Position: Chr3, 56.54 cM, cytoband H1
• Alliance: Neurog2^{tm2(Ncre)Cschu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:310880
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Neurog2^{tm2(Ncre)Cschu} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Neurog2 (MGI:109619)

• Mutation details: A targeting vector replaced the genomic sequence between the Neurog2 START and STOP codon with N-Cre (amino acids 19-59 in Neurog2 locus) modified with a nuclear-localization signal, GCN4 coiled-coil domain, flexible linker, and partial Cre-recombinase sequences. (J:310880)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Neurog2 (mouse) Summary of all recombinase alleles driven by Neurog2. Alliance mouse Neurog2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Neurog2 Mutation: 18 strains or lines available

References

• Original: J:310880 Han S, et al., Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding. Neuron. 2021 Sep 15;109(18):2847-2863.e11
• All: 2 reference(s)