Tg(Sox2-flpo)#Mhem
Transgene Detail

Summary

• Symbol: Tg(Sox2-flpo)#Mhem
• Name: transgene insertion, Myriam Hemberger
• MGI ID: MGI:7460314
• Synonyms: Sox2-Flp, Sox2-FlpO
• Transgene: Tg(Sox2-flpo)#Mhem Location: unknown
• Alliance: Tg(Sox2-flpo)#Mhem page

Transgene origin

• Strain of Origin: DBA x C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Sox2-flpo)#Mhem expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox2 (MGI:98364)

• Mutation details: This transgene expresses FlpO recombinase under the control of a mouse Sox2 promoter contained in a ~13.7 kb genomic fragment encompassing the Sox2. Two founder lines (1.27 and 4.2.28) were established and used in further study. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:333799)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox2 (mouse) Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities Alliance mouse Sox2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:333799 Radford BN, et al., Defects in placental syncytiotrophoblast cells are a common cause of developmental heart disease. Nat Commun. 2023 Mar 1;14(1):1174
• All: 1 reference(s)