Tg(Tyrp1-cre/ERT2)1Jwk
Transgene Detail

Summary

• Symbol: Tg(Tyrp1-cre/ERT2)1Jwk
• Name: transgene insertion 1, Jin Woo Kim
• MGI ID: MGI:7460347
• Transgene: Tg(Tyrp1-cre/ERT2)1Jwk Location: unknown
• Alliance: Tg(Tyrp1-cre/ERT2)1Jwk page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Tyrp1-cre/ERT2)1Jwk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tyrp1 (MGI:98881)

• Mutation details: A DNA fragment encompassing the Tyrp1 promoter region was cloned into a vector containing the cre/ERT2 sequence. The resulting 7.3 kb construct was purified for microinjection into oocytes. (J:314167)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tyrp1 (mouse) Summary of all recombinase alleles driven by Tyrp1. Comparative matrix view of recombinase activities Alliance mouse Tyrp1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:314167 Lim S, et al., mTORC1-induced retinal progenitor cell overproliferation leads to accelerated mitotic aging and degeneration of descendent Muller glia. Elife. 2021 Oct 22;10:e70079
• All: 1 reference(s)