Ets1^tm1Most
Targeted Allele Detail

Summary

• Symbol: Ets1^tm1Most
• Name: E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1, Michael C Ostrowski
• MGI ID: MGI:7460359
• Synonyms: Ets-1^f, Ets-1^flox
• Gene: Ets1 Location: Chr9:32547517-32669116 bp, + strand Genetic Position: Chr9, 17.97 cM
• Alliance: Ets1^tm1Most page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:295291
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exons 7 and 8. An Frt-flanked neomycin selection cassette was inserted downstream of exon 8, followed by a second loxP site. Exons 7 and 8 are thus flanked by loxP sites. (J:295291, J:334073)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ets1 Mutation: 28 strains or lines available

References

• Original: J:295291 Xu L, et al., Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition. BMB Rep. 2019 Oct;52(10):595-600
• All: 4 reference(s)