Coch^{em1(cre)Bcgen}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Coch^{em1(cre)Bcgen}
• Name: cochlin; endonuclease-mediated mutation 1, Biocytogen LLC
• MGI ID: MGI:7461129
• Synonyms: COCH-CRE
• Gene: Coch Location: Chr12:51640156-51652558 bp, + strand Genetic Position: Chr12, 22.11 cM
• Alliance: Coch^{em1(cre)Bcgen} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Coch^{em1(cre)Bcgen} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Coch (MGI:1278313)

• Mutation details: CRE (cyclization recombination enzyme) was knocked in between the Coch Exon 11 and the 3'-untranslated region resulting in protein CRE being appended to the C-terminus of the Coch gene separated by a 2A peptide. (J:328337)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Coch (mouse) Summary of all recombinase alleles driven by Coch. Comparative matrix view of recombinase activities Alliance mouse Coch gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coch Mutation: 43 strains or lines available

References

• Original: J:328337 Jing W, et al., A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h. Cell Rep. 2021 Dec 28;37(13):110177
• All: 1 reference(s)