Scn10a^em1(dre)Fens
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scn10a^em1(dre)Fens
• Name: sodium channel, voltage-gated, type X, alpha; endonuclease-mediated mutation 1, Henning Fenselau
• MGI ID: MGI:7463971
• Synonyms: Nav1.8-p2a-Dre
• Gene: Scn10a Location: Chr9:119437522-119548388 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband distal
• Alliance: Scn10a^em1(dre)Fens page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Scn10a^em1(dre)Fens expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Scn10a (MGI:108029)

• Mutation details: Using the CRISPR/Cas9 system, p2a-Dre was inserted just downstream of the stop codon (exon28) of the Scn10a gene. (J:314805)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Scn10a (mouse) Summary of all recombinase alleles driven by Scn10a. Comparative matrix view of recombinase activities Alliance mouse Scn10a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn10a Mutation: 102 strains or lines available

References

• Original: J:314805 Borgmann D, et al., Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell Metab. 2021 Jul 6;33(7):1466-1482.e7
• All: 1 reference(s)