Krt6a^em1(icre)Vk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Krt6a^em1(icre)Vk
• Name: keratin 6A; endonuclease-mediated mutation 1, Vesa Kaartinen
• MGI ID: MGI:7464182
• Synonyms: Krt6aiCre
• Gene: Krt6a Location: Chr15:101598363-101602746 bp, - strand Genetic Position: Chr15, 56.97 cM
• Alliance: Krt6a^em1(icre)Vk page

Mutation origin

• Strain of Origin: C57BL/6 x SJL

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Krt6a^em1(icre)Vk expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Krt6a (MGI:1100845)

• Mutation details: CRISPR/Cas9 genome editing is used to introduce the iCre-pA cassettes at the Krt6a initiator methionine site in exon 1. (J:325729, J:334621)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Krt6a (mouse) Summary of all recombinase alleles driven by Krt6a. Comparative matrix view of recombinase activities Alliance mouse Krt6a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krt6a Mutation: 25 strains or lines available

References

• Original: J:334621 Saroya G, et al., Periderm Fate during Palatogenesis: TGF-beta and Periderm Dedifferentiation. J Dent Res. 2023 Apr;102(4):459-466
• All: 2 reference(s)