Slc35a3^em1Tfric
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc35a3^em1Tfric
• Name: solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3; endonuclease-mediated mutation 1, Tatsuya Furuichi
• MGI ID: MGI:7464255
• Gene: Slc35a3 Location: Chr3:116463118-116506366 bp, - strand Genetic Position: Chr3, 50.44 cM
• Alliance: Slc35a3^em1Tfric page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 17-bp deletion (c.255_271del) in exon 3. (J:334711)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc35a3 Mutation: 32 strains or lines available

References

• Original: J:334711 Saito S, et al., Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis. PLoS One. 2023;18(4):e0284292
• All: 1 reference(s)