Gad1^{tm3(cre/PGR*)Tama}
Targeted Allele Detail

Summary

• Symbol: Gad1^{tm3(cre/PGR*)Tama}
• Name: glutamate decarboxylase 1; targeted mutation 3, Nobuaki Tamamaki
• MGI ID: MGI:7466336
• Synonyms: GAD67-CrePR
• Gene: Gad1 Location: Chr2:70392109-70432358 bp, + strand Genetic Position: Chr2, 41.63 cM, cytoband D
• Alliance: Gad1^{tm3(cre/PGR*)Tama} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316938
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: mifepristone
• Mutation: Insertion
• Gad1^{tm3(cre/PGR*)Tama} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gad1 (MGI:95632)

• Mutation details: The targeting vector consists of a fusion protein of Cre recombinase plus a modified ligand binding domain of the human progesterone receptor and pgk-neo-polyA cassette followed by a Pgk-neo-p(A) cassette flanked by two Flp recognition target (frt) sites was inserted in the translational initiation site of the Gad1 gene. (J:316938)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gad1 (mouse) Summary of all recombinase alleles driven by Gad1. Comparative matrix view of recombinase activities Alliance mouse Gad1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gad1 Mutation: 65 strains or lines available

References

• Original: J:316938 Esumi S, et al., Characterization and Stage-Dependent Lineage Analysis of Intermediate Progenitors of Cortical GABAergic Interneurons. Front Neurosci. 2021;15:607908
• All: 2 reference(s)