Npr3^{em1(cre/ERT2)Bz}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Npr3^{em1(cre/ERT2)Bz}
• Name: natriuretic peptide receptor 3; endonuclease-mediated mutation 1, Bin Zhou
• MGI ID: MGI:7467076
• Synonyms: Npr3^CreERT2
• Gene: Npr3 Location: Chr15:11839982-11907287 bp, - strand Genetic Position: Chr15, 5.83 cM
• Alliance: Npr3^{em1(cre/ERT2)Bz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317975
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Npr3^{em1(cre/ERT2)Bz} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Npr3 (MGI:97373)

• Mutation details: The allele was generated by knocking in a 2A peptide-linked creERT2 cDNA immediately before the stop codon of the Npr3 by CRISPRCas9 targeting and homozygous recombination in R1 mouse embryonic stem cells. (J:317975)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Npr3 (mouse) Summary of all recombinase alleles driven by Npr3. Comparative matrix view of recombinase activities Alliance mouse Npr3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npr3 Mutation: 49 strains or lines available

References

• Original: J:317975 Lu P, et al., Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signalling. Nat Cell Biol. 2021 Sep;23(9):967-977
• All: 2 reference(s)