Axin2^{tm1.1(cre/ERT2)Niba}
Targeted Allele Detail

Summary

• Symbol: Axin2^{tm1.1(cre/ERT2)Niba}
• Name: axin 2; targeted mutation 1.1, Nick Barker
• MGI ID: MGI:7468751
• Synonyms: Axin2-2A-CreERT2
• Gene: Axin2 Location: Chr11:108811175-108841609 bp, + strand Genetic Position: Chr11, 71.83 cM
• Alliance: Axin2^{tm1.1(cre/ERT2)Niba} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:319855
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Axin2^{tm1.1(cre/ERT2)Niba} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Axin2 (MGI:1270862)

• Mutation details: Sequence for the 2A self-cleaving peptide, a cre-ERT2 fusion gene and a loxP site flanked neomycin resistance gene cassette were inserted immediately before the stop codon. The neo cassette was removed through subsequent cre-mediated recombination. This allele expresses the endogenous peptide and the inserted cre-ERT2 fusion peptide. (J:319855)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Axin2 (mouse) Summary of all recombinase alleles driven by Axin2. Comparative matrix view of recombinase activities Alliance mouse Axin2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Axin2 Mutation: 44 strains or lines available

References

• Original: J:319855 Tan SH, et al., A constant pool of Lgr5(+) intestinal stem cells is required for intestinal homeostasis. Cell Rep. 2021 Jan 26;34(4):108633
• All: 1 reference(s)