Bcl11a^{tm1.1(cre/ERT2)Khal}
Targeted Allele Detail

Summary

• Symbol: Bcl11a^{tm1.1(cre/ERT2)Khal}
• Name: BCL11 transcription factor A; targeted mutation 1.1, Walid T Khaled
• MGI ID: MGI:7468922
• Synonyms: Bcl11a^CreERT2
• Gene: Bcl11a Location: Chr11:24028056-24124123 bp, + strand Genetic Position: Chr11, 14.41 cM
• Alliance: Bcl11a^{tm1.1(cre/ERT2)Khal} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335215
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Bcl11a^{tm1.1(cre/ERT2)Khal} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Bcl11a (MGI:106190)

• Mutation details: The allele was generated by introducing an IRES-CreERT2-polyA-FRT-PGK-E7-Neo-polyA-FRT cassette into the 3UTR of Bcl11a locus by targeted homologous recombination in the ES cells. (J:335215)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Bcl11a (mouse) Summary of all recombinase alleles driven by Bcl11a. Comparative matrix view of recombinase activities Alliance mouse Bcl11a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl11a Mutation: 44 strains or lines available

References

• Original: J:335215 Pensa S, et al., The generation of a Bcl11a lineage tracing mouse model. bioRxiv. 2021 Jul
• All: 2 reference(s)