Mcoln3^{tm1.1(cre)Lrcb}
Targeted Allele Detail

Summary

• Symbol: Mcoln3^{tm1.1(cre)Lrcb}
• Name: mucolipin 3; targeted mutation 1.1, Christian Grimm
• MGI ID: MGI:7469457
• Synonyms: Trpml3^IRES-Cre
• Gene: Mcoln3 Location: Chr3:145823205-145847561 bp, + strand Genetic Position: Chr3, 71.03 cM
• Alliance: Mcoln3^{tm1.1(cre)Lrcb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:320955
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Mcoln3^{tm1.1(cre)Lrcb} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mcoln3 (MGI:1890500)

• Mutation details: The IRES-Cre-PGK-Neomycin cassette was inserted at 5 bp after the stop codon in exon 12 of the Mcoln3 (Trpml3) gene. The resulting mice were crossed with FLP deleter mice to remove the neo cassette. (J:320955)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mcoln3 (mouse) Summary of all recombinase alleles driven by Mcoln3. Comparative matrix view of recombinase activities Alliance mouse Mcoln3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcoln3 Mutation: 35 strains or lines available

References

• Original: J:320955 Spix B, et al., Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. Nat Commun. 2022 Jan 14;13(1):318
• All: 1 reference(s)