Nicol1^em1Osb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nicol1^em1Osb
• Name: NELL2 interacting cell ontogeny regulator 1; endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:7470865
• Synonyms: Nicol^em1Osb
• Gene: Nicol1 Location: Chr5:34140863-34142353 bp, + strand Genetic Position: Chr5, 17.83 cM
• Alliance: Nicol1^em1Osb page

Mutation origin

• Strain of Origin: (C57BL/6NJcl x DBA/2NJcl)F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of the coding region deleted 1,862 bp. (J:335479)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nicol1 Mutation: 13 strains or lines available

References

• Original: J:335479 Kiyozumi D, et al., A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility. Nat Commun. 2023 Apr 24;14(1):2354
• All: 1 reference(s)