Tbx3^{tm4(cre/Esr1*)Moon}
Targeted Allele Detail

Summary

• Symbol: Tbx3^{tm4(cre/Esr1*)Moon}
• Name: T-box 3; targeted mutation 4, Anne M Moon
• MGI ID: MGI:7471384
• Synonyms: tbx3^mcm, Tbx3^mcm
• Gene: Tbx3 Location: Chr5:119808734-119822789 bp, + strand Genetic Position: Chr5, 60.34 cM
• Alliance: Tbx3^{tm4(cre/Esr1*)Moon} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232111
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tbx3^{tm4(cre/Esr1*)Moon} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx3 (MGI:98495)

• Mutation details: The targeting construct inserted an IRES sequence followed by the mER:Cre:mER cDNA encoding a fusion protein with two copies of the mouse estrogen receptor (mER) flanking Cre recombinase, and a Neomycin resistance (NeoR) selection cassette flanked by Frt recombination sites in the Tbx3 gene. (J:232111)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx3 (mouse) Summary of all recombinase alleles driven by Tbx3. Comparative matrix view of recombinase activities Alliance mouse Tbx3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx3 Mutation: 49 strains or lines available

References

• Original: J:232111 Emechebe U, et al., T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. Elife. 2016;5:e07897
• All: 2 reference(s)