Prf1^em2(cre)Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Prf1^em2(cre)Smoc
• Name: perforin 1 (pore forming protein); endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:7482335
• Synonyms: Prf1/IRES-EGFP-T2A-Cre
• Gene: Prf1 Location: Chr10:61133612-61140459 bp, + strand Genetic Position: Chr10, 32.18 cM
• Alliance: Prf1^em2(cre)Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase, Reporter)
• Mutation: Insertion
• Prf1^em2(cre)Smoc expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Prf1 (MGI:97551)

• Mutation details: Using CRISPR targeting, the IRES-EGFP-T2A-Cre sequence was inserted just before the stop codon of the Prf1. (J:322580)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prf1 (mouse) Summary of all recombinase alleles driven by Prf1. Alliance mouse Prf1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prf1 Mutation: 51 strains or lines available

References

• Original: J:322580 Pan Y, et al., Inhibition of Perforin-Mediated Neurotoxicity Attenuates Neurological Deficits After Ischemic Stroke. Front Cell Neurosci. 2021;15:664312
• All: 1 reference(s)