Tg(Fgf1-RFP,-cre/ERT2)13AChiu
Transgene Detail

Summary

• Symbol: Tg(Fgf1-RFP,-cre/ERT2)13AChiu
• Name: transgene insertion 13A, Ing-Ming Chiu
• MGI ID: MGI:7482681
• Synonyms: F1A-CreER^T2
• Transgene: Tg(Fgf1-RFP,-cre/ERT2)13AChiu Location: unknown
• Alliance: Tg(Fgf1-RFP,-cre/ERT2)13AChiu page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Mutation: Insertion
• Tg(Fgf1-RFP,-cre/ERT2)13AChiu expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fgf1 (MGI:95515)

• Mutation details: The 131.5 kb transgene consists of an RFP-IRES-CreERT2polyA expression cassette inserted into a mouse bacterial artificial chromosome (BAC) clone RP23-193N23 including Fgf1 5' UTR (127.7 kb), exon 1A, and 1B sequence containing the promoter for alternatively spliced to the first protein-coding exon 1A isoform predominantly expressed in the heart. Three founders 13A, 22A, and 25A were confirmed. Line #13A with the highest expression of Cre recombinase in the heart was chosen for all the following studies. (J:323281)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fgf1 (mouse) Summary of all recombinase alleles driven by Fgf1. Comparative matrix view of recombinase activities Alliance mouse Fgf1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:323281 Hsu YC, et al., Establishing F1A-CreER(T2) Mice to Trace Fgf1 Expression in Adult Mouse Cardiomyocytes. Cells. 2021 Dec 30;11(1)
• All: 1 reference(s)