Tigit^{em1(cre/ERT2)Tebi}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tigit^{em1(cre/ERT2)Tebi}
• Name: T cell immunoreceptor with Ig and ITIM domains; endonuclease-mediated mutation 1, Takashi Ebihara
• MGI ID: MGI:7484293
• Synonyms: Tigit-Cre-ERT2
• Gene: Tigit Location: Chr16:43469230-43484509 bp, - strand Genetic Position: Chr16, 28.44 cM
• Alliance: Tigit^{em1(cre/ERT2)Tebi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335476
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Mutation: Insertion
• Tigit^{em1(cre/ERT2)Tebi} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tigit (MGI:3642260)

• Mutation details: The IRES-EGFP-Cre-ERT2 cassette was inserted into the 3' untranslated region of the Tigit gene in 129 ES cells by CRISPR/Cas9 method. (J:335476)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tigit (mouse) Summary of all recombinase alleles driven by Tigit. Comparative matrix view of recombinase activities Alliance mouse Tigit gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tigit Mutation: 27 strains or lines available

References

• Original: J:335476 Yamada T, et al., TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy. J Exp Med. 2023 Jul 3;220(7)
• All: 1 reference(s)