Gas1^{em1(icre/ERT2)Nono}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gas1^{em1(icre/ERT2)Nono}
• Name: growth arrest specific 1; endonuclease-mediated mutation 1, Noriaki Ono
• MGI ID: MGI:7484373
• Synonyms: Gas1-creER
• Gene: Gas1 Location: Chr13:60322219-60325179 bp, - strand Genetic Position: Chr13, 31.92 cM, cytoband B3-C2
• Alliance: Gas1^{em1(icre/ERT2)Nono} page

Mutation origin

• Strain of Origin: (C57BL/6J x SJL/J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Gas1^{em1(icre/ERT2)Nono} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gas1 (MGI:95655)

• Mutation details: using CRISPR/Cas9 endonuclease-mediated genome editing, P2A-iCreERT2-bGH polyA sequences were inserted into the 3' UTR region of the growth arrest specific 1 (Gas1) gene on chromosome 13. (J:335639)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gas1 (mouse) Summary of all recombinase alleles driven by Gas1. Comparative matrix view of recombinase activities Alliance mouse Gas1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gas1 Mutation: 14 strains or lines available

References

• Original: J:335639 Matsushita Y, et al., Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis. Nat Commun. 2023 Apr 25;14(1):2383
• All: 1 reference(s)